Poor Parasympathetic Function Measured by Deep Breathing Linked to Early Stopping of Oral Semaglutide in Type 2 Diabetes

The study investigates the association between the coefficient of variation of R-R intervals and discontinuation rates of oral semaglutide within 6 months.

• Glucagon-like peptide-1 receptor agonists are commonly prescribed for managing type 2 diabetes, yet gastrointestinal issues lead to many patients stopping treatment early.
• Understanding the predictors of discontinuation for oral semaglutide is crucial for improving patient adherence.
• The research assesses whether variations in heart rate intervals could provide insights into the likelihood of discontinuing oral semaglutide treatment.
• Findings may help identify patients at higher risk of discontinuation due to gastrointestinal intolerance.

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