Full text is available at the source.
Abstract
Transient changes in motor and non-motor symptoms are common in Parkinson's disease, independent of medication effects.
- Motor symptoms can fluctuate from brief episodes of gait freezing or tremor breakthroughs to severe akinetic crises.
- Non-motor symptoms may include discontinuous changes in cognition and vigilance.
- Disease-related factors, such as dementia and disturbances in circadian rhythms, may contribute to these fluctuations.
- External factors like infections, surgery, and general anesthesia could also lead to changes in symptom severity and medication response.
- Accurate classification of these symptom oscillations is crucial for effective management.
Simplified