Paroxetine treatment of generalized anxiety disorder.

Oct 21, 2003Psychopharmacology bulletin

Paroxetine treatment for generalized anxiety disorder

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Abstract

Generalized anxiety disorder (GAD) is believed to affect at least 5% of the general population.

GAD is characterized by chronic and uncontrollable worry, anxiety, and tension.
These symptoms can hinder social, professional, and family roles.
Effective pharmacologic treatments should have both anxiolytic and antidepressive properties due to high comorbidity with other psychiatric disorders.
Paroxetine is the best studied SSRI for GAD and is the only one approved by the US Food and Drug Administration for this condition.
Randomized controlled studies indicate that paroxetine is effective for the short-term treatment of GAD and can help achieve and sustain full remission.

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Generalized anxiety disorder (GAD) is a prevalent and disabling anxiety disorder, conservatively believed to affect at least 5% of the general population. Cardinal symptoms of GAD include chronic and uncontrollable worry, anxiety, and tension, which result in difficulty fulfilling social, professional, and family roles. Treatment options include benzodiazepines, tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and the serotonin-norepinephrine reuptake inhibitor (SNRI) venlafaxine XR. Because of the high comorbidity of GAD with other psychiatric disorders, pharmacologic therapy should possess both anxiolytic and antidepressive properties for best outcomes. The SSRIs are a good treatment option, and paroxetine is the best studied SSRI for GAD and the only SSRI to date approved by the US Food and Drug Administration for this indication. Results of randomized, controlled studies of paroxetine have demonstrated its efficacy in the short-term treatment of GAD, in achieving and sustaining full remission, and in preventing relapse. This article provides an overview of GAD and a discussion of studies of paroxetine treatment in this anxiety disorder.

Paroxetine treatment of generalized anxiety disorder.

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