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PARP1 limits Epstein Barr Virus reactivation by attaching to the virus's control region
Updated
Abstract
Knockdown of PARP1 in the Akata-EBV cell line significantly increases viral copy number and lytic protein expression.
- Binding of PARP1 at the BZLF1 lytic switch promoter restricts Epstein Barr virus (EBV) reactivation.
- CTCF knockdown does not affect EBV reactivation, indicating its limited role in this process.
- CTCF binding across the EBV genome remains largely unchanged during viral reactivation.
- EBV reactivation reduces PARP activity, which may influence viral behavior.
- Zta expression alone is sufficient to decrease PARP activity, suggesting a regulatory mechanism.
Simplified