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Abstract
Extracellular vesicles (EVs) are implicated in the complex degenerative processes of osteoarthritis (OA).
- Osteoarthritis is characterized by progressive joint degeneration and chronic inflammation affecting various joint components.
- EVs play a significant role in communication within the OA joint microenvironment and may influence disease progression.
- These vesicles can carry nucleic acids, proteins, and lipids that may exacerbate conditions such as synovitis and cartilage breakdown.
- EVs also have the potential to support repair processes in the joint.
- Understanding how EVs are formed, their contents, and their specific roles could lead to new biomarkers and therapies for OA.
- Current EV-based strategies for OA are primarily in the preclinical phase and require further validation for clinical application.
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