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Pathophysiology and pharmacological management for sleep problems in Parkinson's disease
Causes and drug treatments of sleep problems in Parkinson's disease
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Abstract
Sleep problems affect a significant number of individuals with Parkinson's disease, presenting as various disorders.
- Common sleep disturbances in Parkinson's disease include insomnia, REM sleep behavior disorder, restless legs syndrome, excessive daytime sleepiness, and sleep-related breathing disorders.
- The complexity of these disturbances increases with the severity of Parkinson's disease.
- Sleep disorders may significantly impact patients' quality of life and could worsen both motor and non-motor symptoms.
- Proposed mechanisms for these sleep disorders include neurodegenerative processes, neurotransmitter dysfunction, medication side effects, and circadian rhythm disruptions.
- Despite high prevalence, treatment options for sleep disturbances in Parkinson's disease remain limited.
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