PD1⁺ Tumor Associated Macrophages Predict Poor Prognosis of Locally Advanced Esophageal Squamous Cell Carcinoma

Oct 16, 2019Future oncology (London, England)

Immune cells with PD1 in esophageal cancer linked to worse outcomes

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Abstract

CD68PD1 macrophages increased approximately 4.2 times in cancer tissues compared to para-cancer tissues.

CD68PD1 macrophages express higher levels of M2 markers in esophageal squamous cell carcinoma (ESCC).
These macrophages are significantly associated with more aggressive cancer traits and poorer patient outcomes.
Treatment with PD1 can enhance the ability of macrophages to engulf cancer cells and promote a shift towards a more aggressive M1-like phenotype.
Overall, CD68PD1 macrophages may serve as a prognostic indicator for ESCC.

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Tumor associated macrophages are the most abundant cancer immune cells. However, little was known about the identity of CD68PD1macrophages as well as the contributions in the prognosis of esophageal squamous cell carcinoma (ESCC).Immunofluorescence, flowcytometry and RT-PCR were used to analysis PD1macrophages in ESCC.CD68PD1macrophages which can express higher M2 markers in cancer tissues, increased about 4.2-times compared with para-cancer tissues. Additionally, PD1macrophages were significantly correlated with more malignant phenotypes and poor prognosis. PD1 treatment can enhance phagocytosis of cultured macrophages and redirect this macrophage to M1-like phenotype.Thus, our findings overall indicate that CD68PD1macrophages are tumor associated macrophagess in ESCC, which can forecast the prognosis of ESCC. Aim: Methods & methods: Results: Conclusion: + + + + + high + +

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PD1⁺ Tumor Associated Macrophages Predict Poor Prognosis of Locally Advanced Esophageal Squamous Cell Carcinoma

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