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PDGF-B Is Required for Development of the Glymphatic System
PDGF-B is needed for the development of the brain’s waste clearance system
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Abstract
Perivascular cerebrospinal fluid transport first appears in the hippocampus of newborn mice.
- A mature glymphatic system is established in the cortex by 2 weeks of age.
- The formation of specialized endfeet in brain cells is linked to the onset of perivascular CSF transport.
- The expression of aquaporin 4 (AQP4) is polarized and coincides with the development of CSF transport pathways.
- Deficiency in platelet-derived growth factor B (PDGF-B) impairs the development of the glymphatic system in knockout mice.
- The functions of the glymphatic system remain suppressed in adulthood in mice lacking PDGF-B.
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