Research squareJan 16, 2026

Ongoing Immune Problems in Long COVID Linked to Antibodies Against Virus Shell and Core Proteins

Long Covid Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated Jan 17, 2026

Abstract

Participants with Long COVID exhibited persistently elevated IgG titers for SARS-CoV-2 proteins over 6 months.

Long COVID participants demonstrated a broad range of immune dysregulation compared to those who recovered without complications.
SARS-CoV-2-specific antibody responses were characterized by persistently high levels of IgG against Envelope and Nucleocapsid proteins in Long COVID cases.
The IgG responses to Spike protein were significantly lower in the Long COVID cohort, with a bias towards IgG1 and IgG3 classes.
Elevated numbers of circulating T follicular helper cells and mucosa-associated invariant T cells correlated with high anti-Envelope IgG titers.
Long COVID participants exhibited increased serum cytokines such as LIF, IL-11, Eotaxin-3, and HMGB-1, alongside higher rates of autoantibodies.

Simplified

Long COVID (LC) or Post-Acute Sequelae of SARS-CoV-2 infection (PASC) syndrome represents a widespread health challenge that necessitates the development of novel diagnostic approaches and targeted therapies that can be readily deployed. Immune dysregulation has been reported as one of the hallmarks of LC, but the extent of LC immune dysregulation in patients over time remains unclear. We therefore assessed SARS-CoV-2-specific antibody responses, peripheral immune cell profiles, autoantibody profiles and circulating cytokines for up to 6 months in participants with a SARS-CoV-2 infection who either convalesced or developed LC. Compared to convalescent, LC participants with a broad range of LC phenotypes exhibited persistently elevated IgG titers for SARS-CoV-2 Envelope and Nucleocapsid proteins over the 6 months of study duration. In contrast, the IgG responses to Spike protein were significantly lower in the LC cohort with predominantly IgG1 and IgG3 class-switched bias. Using CyTOF analysis we show elevated numbers of circulating T follicular helper cells (cTFH) and mucosa- associated invariant T cells (MAIT), which also correlated with high anti-Envelope IgG titers. Persistent immune activation was accompanied by augmented serum cytokine profiles with LIF, IL-11, Eotaxin-3, and HMGB-1 in LC participants, who also demonstrated significantly higher rates of autoantibodies. These findings highlight the persistence of immune dysregulation in LC, underscoring the need to explore targeted therapies addressing viral persistence, dysregulated antibody production, and autoimmunity.

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Ongoing Immune Problems in Long COVID Linked to Antibodies Against Virus Shell and Core Proteins

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