Persistent Rotating Shift-Work Exposure Accelerates Development of Metabolic Syndrome among Middle-Aged Female Employees: A Five-Year Follow-Up

Among 387 female industrial employees, those with persistent rotating shift work had a significantly raised risk of developing metabolic syndrome, with an odds ratio of 3.5 compared to day workers.

• The initial mean age of subjects was 32.8 years.
• Higher baseline abnormal rates for metabolic syndrome components and insulin resistance were found in the 34 female workers who developed metabolic syndrome.
• Persistent exposure to rotating shift work was linked to unfavorable changes in metabolic syndrome components over five years.
• Smokers had an increased risk of developing metabolic syndrome, with an odds ratio of 5.4 compared to non-smokers.
• Female workers with one or two metabolic syndrome components initially faced a 4.6-fold and 12.7-fold increased risk, respectively, of progressing to metabolic syndrome within five years.

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