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Abstract
PFKM suppression triggers distinctive donut-shaped mitochondria and enhances bone repair in rat models.
- Osteogenic differentiation is linked to mitochondrial adaptation to bioenergetic demands.
- PFKM, traditionally a glycolytic enzyme, plays a non-canonical role in mitochondrial remodeling during bone formation.
- Knocking down Pfkm leads to the formation of donut-shaped mitochondria through a novel signaling cascade.
- Increased mitochondria-endoplasmic reticulum contacts facilitate mitochondrial calcium influx.
- Elevated CD38 reduces protein kinase A activity, resulting in DRP1 dephosphorylation and mitochondrial translocation.
- This process enhances mitochondrial quality control, including biogenesis and selective mitophagy, optimizing cellular mineralization.
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