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Abstract
GIP stimulated insulin secretion and increased whole-body glucose disposal during hyperglycemia in individuals with type 2 diabetes.
- Pharmacological GIP infusion was associated with a modest reduction in glucagon suppression.
- Insulin sensitivity was impaired during GIP infusion despite increased glucose disposal.
- GIP infusion also augmented heart rate and led to reduced blood pressure.
- These findings suggest that GIP retains biological activity in type 2 diabetes.
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