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Pharmacological inhibition of acyl-coenzyme A:cholesterol acyltransferase alleviates obesity and insulin resistance in diet-induced obese mice by regulating food intake
Blocking a cholesterol-processing enzyme reduces obesity and insulin resistance by controlling food intake in diet-induced obese mice
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Abstract
Avasimibe treatment resulted in a marked decrease in body weight and body fat content in high-fat diet-induced obese mice.
- Avasimibe significantly reduced food intake and increased energy expenditure in obese mice.
- Blood levels of glucose and insulin decreased following avasimibe treatment, indicating improved glucose tolerance.
- The effects of avasimibe were linked to lower levels of genes associated with fat cell function in adipose tissue.
- Weight loss from avasimibe was primarily attributed to reduced food intake, as shown in a pair-feeding study.
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