Pharmacological management of pediatric metabolic dysfunction‐associated steatotic liver disease

Nov 11, 2024Journal of pediatric gastroenterology and nutrition

Drug treatments for children with fatty liver disease linked to metabolic problems

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Abstract

Pediatric obesity affects a substantial number of children and adolescents worldwide, with metabolic dysfunction-associated steatotic liver disease (MASLD) emerging as a significant consequence.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent liver disorder among pediatric patients.
The rise in pediatric MASLD correlates with increasing childhood obesity rates over recent decades.
Standard lifestyle modifications often fail to achieve and maintain significant weight reduction in affected children.
Glucagon-like peptide-1 receptor agonists (GLP-1RA) have shown promise in promoting weight loss and improving liver enzyme levels in pediatric obesity and MASLD.
There is a potential for GLP-1RA to halt the progression of MASLD and reduce the risk of severe liver outcomes.
Further research is needed to determine the long-term safety and effectiveness of GLP-1RA in pediatric populations.

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Pediatric obesity, characterized by a body mass index (BMI) at or above the 95th percentile for age, affects a substantial number of children and adolescents worldwide. Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease, represents a prominent hepatic manifestation of obesity and metabolic syndrome, emerging as the most prevalent hepatic disorder among pediatric patients and a significant contributor to liver transplantation in adults. The escalating prevalence of pediatric MASLD mirrors the alarming rise in childhood obesity rates over recent decades. While lifestyle modifications focusing on dietary changes and increased physical activity constitute the cornerstone of MASLD management, achieving and maintaining significant weight reduction remains challenging. Moreover, disease progression often persists despite standard-of-care interventions, warranting exploration into alternative therapeutic strategies. Pharmacological interventions, particularly, glucagon-like peptide-1 receptor agonists (GLP-1RA), have shown promise in addressing pediatric obesity and its associated comorbidities, including MASLD. Recent studies have demonstrated the efficacy of GLP-1RA in inducing weight loss and improving liver enzyme levels, suggesting a potential role in halting disease progression, and reducing the risk of major adverse liver outcomes. This review provides a comprehensive overview of the current pharmacotherapy landscape for pediatric MASLD, with a focus on novel agents such as GLP-1RA. Furthermore, the manuscript proposes a practical algorithm to assist in integrating GLP-1RA into the clinical management of pediatric patients with obesity and MASLD. Despite promising results, further research is warranted to elucidate the long-term efficacy and safety of GLP-1RA in pediatric populations.

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Pharmacological management of pediatric metabolic dysfunction‐associated steatotic liver disease

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