Drug discovery today

How Gut Microbes Influence Drug Responses in Brain Disorders

Updated

Abstract

Gut microbes may significantly influence drug metabolism and responses in neuroactive medications.

  • Pharmacomicrobiomics examines how gut microbiota impacts drug metabolism, efficacy, and safety.
  • Dysbiosis can alter drug responses by affecting neurotransmitter production and immune function.
  • Variations in the microbiome are associated with different treatment responses in brain disorders.
  • Integrating pharmacomicrobiomics into neuropharmacology could lead to more personalized medicine.
  • Emerging microbiome-targeted strategies aim to enhance therapeutic effectiveness and minimize side effects in neuropsychiatric and neurodegenerative conditions.

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