The Mitigating Effect of Phentermine and Topiramate on Weight Regain After Roux‐en‐Y Gastric Bypass Surgery

Phentermine and topiramate may significantly reduce weight regain after Roux-en-Y gastric bypass surgery in patients.

• Weight regain after gastric bypass surgery starts to occur approximately 2 years post-operation and affects at least 25% of patients.
• A review of electronic medical records from 1,196 patients who underwent surgery identified a subset of 760 patients who reached their lowest weight after the procedure.
• Statistical analysis indicated that the use of antiobesity medications, specifically phentermine and topiramate, is associated with a reduction in weight regain.
• The study found a consistent effect of these medications across multiple statistical models, despite the absence of a unified protocol for their use.

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