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Abstract
Pigment-dispersing factor (PDF) plays a critical role in circadian timekeeping in insects.
- PDF is expressed in relatively few neurons within insect nervous systems.
- It is best known for its function in regulating circadian rhythms.
- Evidence suggests that PDF acts as an output factor of the circadian clock.
- Emerging models indicate how PDF operates within the circadian clock neuron network.
- The most detailed understanding of PDF's roles comes from studies in Drosophila.
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