Eight weeks of aerobic exercise during active and rest phases changes stem cell gene levels in bone of diabetic mice

Diabetes mellitus is associated with reduced activity of key pluripotency genes in bone tissue.

• Chronic hyperglycemia, oxidative stress, and inflammation may impair bone metabolism in diabetes.
• Reduced osteoblast activity is observed in diabetic conditions.
• Key pluripotency genes such as OCT4, NANOG, SOX2, and REX1 show downregulation in diabetic mice.
• The timing of aerobic exercise may influence gene expression related to pluripotency in bone tissue.

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