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Plasma biomarkers, brain amyloid pathology, and cortical thickness in a diverse middle-aged community cohort: the HCP-CoBRA study
Blood markers, brain amyloid buildup, and brain thickness in a diverse group of middle-aged adults
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Abstract
P-tau217 exhibited high sensitivity and specificity (>85%) for Aβ-PET status in a cohort of 218 participants.
- Plasma biomarkers were evaluated for their association with Aβ-PET and cortical thickness in a biracial cohort.
- All biomarkers except p-tau231 were effective in ruling out Aβ-pathology, showing a negative predictive value greater than 95%.
- Only Janssen p-tau217+ demonstrated strong accuracy for confirming Aβ-pathology with a positive predictive value of 0.909.
- Plasma biomarkers showed limited predictive capability for cortical thickness despite elevations linked to joint Aβ-PET and neurodegeneration profiles.
- Correlation with Aβ-PET varied by self-identified race, indicating potential differences in biomarker performance.
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