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Plasma biomarkers identify brain ATN abnormalities in a dementia-free population-based cohort
Blood markers linked to amyloid, tau, and nerve cell changes in the brain of people without dementia
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Abstract
Plasma p-tau217 demonstrates the highest classification accuracy for abnormal brain amyloid-beta status, with an area under the curve (AUC) of 0.94.
- Plasma biomarkers Aβ42/Aβ40, p-tau181, and p-tau217 are significantly associated with abnormal amyloid-beta PET status, indicated by adjusted odds ratios of 1.74, 1.47, and 3.43, respectively.
- Plasma p-tau181 and p-tau217 are significantly associated with status, with odds ratios of 1.50 and 22.24, respectively.
- The classification accuracies for tau PET status are comparable for p-tau181 and p-tau217, with AUCs of 0.74 and 0.70, respectively.
- Only plasma neurofilament light chain () shows a significant association with neurodegeneration based on cortical thickness, with an odds ratio of 1.09.
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Key numbers
0.94
Classification Accuracy of p-tau217
AUC for plasma p-tau217 distinguishing status
22.24
Adjusted Odds Ratio for p-tau217 with
AOR for plasma p-tau217 associated with status
1.09
Adjusted Odds Ratio for with neurodegeneration
AOR for plasma associated with neurodegeneration status