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Abstract
PCOS is the most prevalent heterogeneous endocrine disorder.
- PCOS is characterized by hyperandrogenism, anovulation, ovarian dysfunction, and polycystic ovarian morphology.
- Its pathogenesis may involve interconnected pathways such as neuroendocrine dysregulation and insulin resistance.
- Alterations in ovarian hormone production and imbalances in LH/FSH ratios are associated with the condition.
- Recent advances in drug repurposing highlight potential new therapies targeting kisspeptin pathways and neurokinin B receptors.
- Glucagon-like peptide (GLP-1) agonists and sodium-glucose cotransporter-2 (SGLT-2) inhibitors may offer promising management strategies.
- Further research is needed to develop phenotype-specific treatments that address menstrual irregularity, metabolic dysregulation, and infertility.
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