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The effects of potassium channel openers on isolated pregnant human myometrium before and after the onset of labor: Potential for tocolysis
Potassium channel openers' effects on pregnant uterine muscle before and after labor: possible use to delay childbirth
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Abstract
Levcromakalim and pinacidil are potent inhibitors of contractions in isolated pregnant human myometrium.
- Both potassium channel openers effectively reduced spontaneous and induced contractions in myometrial samples from 67 women.
- The inhibition of contractions occurred with low concentrations of extracellular potassium chloride but not with high concentrations.
- Glibenclamide acted as a competitive antagonist to the inhibitory effects of levcromakalim and pinacidil.
- No antagonistic effect was observed with tolbutamide.
- These findings indicate that activating potassium channels may contribute to muscle relaxation in the pregnant uterus.
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