PPARα is involved in photoentrainment of the circadian clock

Bezafibrate advanced the active phase of mice under long photoperiod conditions (18 hours of light).

• The onset of activity in mice was gradually advanced by bezafibrate when exposed to a long light period.
• Under a long photoperiod (18:6), the active phase was almost completely shifted from the dark to the light period.
• No change in activity onset was observed under short photoperiod (8:16) or constant light conditions.
• The findings suggest a potential role of PPARalpha in adjusting the circadian clock to different light-dark environments.

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