Predictors of functional response and remission with desvenlafaxine 50 mg/d in patients with major depressive disorder

Patients treated with desvenlafaxine 50 mg/d showed 40% achieving functional response at week 8, compared to 31% for placebo.

• Functional response was defined as a Sheehan Disability Scale (SDS) score of ≤12 and a ≥50% improvement in SDS.
• Functional/depression response included a functional response plus a ≥50% improvement in the Hamilton Rating Scale for Depression score.
• Functional remission required an SDS score of <7, while functional/depression remission required both SDS < 7 and Hamilton Rating Scale score ≤7.
• Early improvement in SDS by week 2 was a strong predictor of later functional response or remission.
• Odds ratios indicated a significant association between early SDS improvement and treatment success.

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