Preoperative Depression Status and 5 Year Metabolic and Bariatric Surgery Outcomes in the PCORnet Bariatric Study Cohort

Jan 21, 2022Annals of surgery

Pre-surgery Depression and 5-Year Weight and Health Results After Bariatric Surgery

AI simplified

GLP-1 Therapies on OpenScience ↗PubMed ↗DOI ↗OA ↗

Abstract

27.1% of sleeve gastrectomy and 33.0% of gastric bypass patients had preoperative depression.

Patients with preoperative depression experienced slightly less weight loss after gastric bypass compared to those without depression.
No significant difference in weight loss was observed for sleeve gastrectomy patients based on depression status.
Improvements in blood sugar levels () were slightly greater for depressed patients after gastric bypass.
Depression status did not influence diabetes remission or relapse rates, nor did it affect reoperations, revisions, or mortality across both surgical procedures.
Depression was associated with an increased risk of needing endoscopy and repeat hospitalizations after gastric bypass compared to sleeve gastrectomy.

AI simplified

OBJECTIVE: To examine whether depression status before (MBS) influenced 5-year weight loss, diabetes, and safety/utilization outcomes in the PCORnet Bariatric Study.

SUMMARY OF BACKGROUND DATA: Research on the impact of depression on MBS outcomes is inconsistent with few large, long-term studies.

METHODS: Data were extracted from 23 health systems on 36,871 patients who underwent sleeve gastrectomy (SG; n=16,158) or gastric bypass (RYGB; n=20,713) from 2005-2015. Patients with and without a depression diagnosis in the year before MBS were evaluated for % total weight loss (%TWL), diabetes outcomes, and postsurgical safety/utilization (reoperations, revisions, endoscopy, hospitalizations, mortality) at 1, 3, and 5 years after MBS.

RESULTS: 27.1% of SG and 33.0% of RYGB patients had preoperative depression, and they had more medical and psychiatric comorbidities than those without depression. At 5 years of follow-up, those with depression, versus those without depression, had slightly less %TWL after RYGB, but not after SG (between group difference = 0.42%TWL, P = 0.04). However, patients with depression had slightly larger improvements after RYGB but not after SG (between group difference = - 0.19, P = 0.04). Baseline depression did not moderate diabetes remission or relapse, reoperations, revision, or mortality across operations; however, baseline depression did moderate the risk of endoscopy and repeat hospitalization across RYGB versus SG.

CONCLUSIONS: Patients with depression undergoing RYGB and SG had similar weight loss, diabetes, and safety/utilization outcomes to those without depression. The effects of depression were clinically small compared to the choice of operation.

Key numbers

27.1% of SG patients

Patients with Depression

Percentage of sleeve gastrectomy patients diagnosed with depression preoperatively.

0.42%TWL

Weight Loss Difference

Difference in % total weight loss after RYGB between patients with and without depression at 5 years.

-0.19

Improvement

Change in levels for patients with depression after RYGB compared to those without.

Full Text

We can’t show the full text here under this license. Use the link below to read it at the source.

View full text ↗

Preoperative Depression Status and 5 Year Metabolic and Bariatric Surgery Outcomes in the PCORnet Bariatric Study Cohort

Abstract

Key numbers

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the glp-1 therapies brief

Abstract

Key numbers

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the glp-1 therapies brief