Editing the MTARC1 A165T gene variant in human liver models shows lower fat buildup, inflammation, and scarring

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent cause of chronic liver disease worldwide.

• MASLD is characterized by fat accumulation in the liver, which can lead to inflammation, scarring, and cancer.
• Genetic factors play a role in the development and progression of MASLD.
• Genome-wide association studies have found specific genetic variations, called single-nucleotide polymorphisms (SNPs), that may alter the risk of developing MASLD.
• The MTARC1 gene variant rs2642438 (p.A165T) is noted to have a protective effect against MASLD.
• The specific functions of MTARC1 and the influence of the rs2642438 variant in liver cells are not well understood.

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