Probiotics and antimicrobial proteinsOct 22, 2025

Probiotic Akkermansia muciniphila Helps Fight Obesity

GLP-1 Therapies Weekly Brief ↗PubMed ↗DOI ↗

Updated Jan 2, 2026

Abstract

P-AKK PROBIO administration reduced body weight and body fat percentage by 15.24% and 28.82% over four weeks in obese mice.

P-AKK PROBIO significantly improved liver fat accumulation and serum lipid profiles, decreasing total cholesterol, triglycerides, and low-density lipoprotein cholesterol.
The treatment enhanced intestinal barrier function by increasing the levels of tight junction proteins.
P-AKK PROBIO restored gut microbial balance, indicated by a decreased Firmicutes/Bacteroidetes ratio and enrichment of beneficial bacteria.
The intervention increased production of short-chain fatty acids, particularly propionate, acetate, and butyrate.
Elevated GLP-1 levels were observed in hypothalamic and ileal tissues, suggesting a role in appetite regulation and lipid metabolism.
P-AKK PROBIO may influence key metabolic pathways by activating AMPK/PPAR-α signaling and inhibiting PPAR-γ pathways.

Simplified

Obesity pathogenesis is closely linked to gut microbiota dysbiosis. Akkermansia muciniphila (A. muciniphila) has emerged as a promising next-generation probiotic candidate due to its metabolic benefits. In this study, we systematically evaluated the therapeutic efficacy of pasteurized A. muciniphila AKK PROBIO (P-AKK PROBIO) in high-fat diet (HFD)-induced obese C57BL/6J mice. The results revealed that P-AKK PROBIO administration significantly ameliorated hepatic steatosis and reduced body weight and body fat percentage by 15.24% and 28.82% over four weeks, respectively. The intervention also improved serum lipid profiles by reducing total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C), while increasing high-density lipoprotein cholesterol (HDL-C). Furthermore, P-AKK PROBIO attenuated TNF-α-mediated inflammatory responses. Mechanistically, P-AKK PROBIO enhanced intestinal barrier integrity through upregulation of tight junction proteins (ZO-1 and Occludin) and restored gut microbial homeostasis, as indicated by a decreased Firmicutes/Bacteroidetes ratio. Notably, the treatment enriched beneficial bacterial taxa (Oscillospiraceae and Roseburia) and increased short-chain fatty acids (SCFAs) production, particularly propionate, acetate, and butyrate. These microbial alterations correlated with elevated GLP-1 levels in both hypothalamic and ileal tissues, suggesting a dual mechanism involving GLP-1-dependent appetite regulation and lipid metabolism modulation. Furthermore, P-AKK PROBIO probably regulated key metabolic pathways by upregulating AMPK/PPAR-α signaling while downregulating PPAR-γ cascades. Collectively, these findings provide compelling evidence supporting the potential development of pasteurized A. muciniphila formulations for the management of metabolic disorders.

Full Text

Full text is available at the source.

View Full Text ↗

Probiotic Akkermansia muciniphila Helps Fight Obesity

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the glp-1 therapies brief