Gut

Probiotic fermented dairy's impact on memory-related brain chemicals, structure, and function in healthy women over 8 weeks

Updated

Abstract

Essence

An 8-week probiotic fermented dairy intervention showed preliminary effects on hippocampal-related measures in healthy women.

Evidence

This triple-blind randomized placebo-controlled trial assigned 40 healthy women aged 18-55 years to 130 g per day of probiotic yoghurt or placebo and measured hippocampal metabolites, imaging outcomes, microbiome changes, symptoms, memory, and blood markers.

Caveat

The main metabolite and brain-volume differences did not withstand correction for multiple comparisons, and most secondary measures showed no differences, making the signal preliminary in a small healthy-women sample.

Simplified

Full Text

Full text is available at the source.

Funding

Competing interests

Competing interests: WM has previously received funding from the Cancer Council Queensland and university grants/fellowships from La Trobe University, Deakin University, University of Queensland, and Bond University. WM has received funding and/or has attended events funded by Cobram Estate Pty. Ltd and Bega Dairy and Drinks Pty Ltd. WM has received travel funding from Nutrition Society of Australia. WM has received consultancy funding from Nutrition Research Australia and ParachuteBH. WM has received speakers honoraria from VitaFoods, The Cancer Council Queensland and the Princess Alexandra Research Foundation. WM is the current President of the International Society for Nutritional Psychiatry Research (unpaid). AM is immediate past Secretary for the International Society for Nutritional Psychiatry Research (unpaid). MB has received Grant/Research Support from the NIH, Cooperative Research Centre, Simons Autism Foundation, Cancer Council of Victoria, Stanley Medical Research Foundation, Medical Benefits Fund, National Health and Medical Research Council, Medical Research Futures Fund, Beyond Blue, Rotary Health, A2 milk company, Meat and Livestock Board, Woolworths, Avant and the Harry Windsor Foundation, has been a speaker for Abbot, Astra Zeneca, Janssen and Janssen, Lundbeck and Merck and served as a consultant to Allergan, Astra Zeneca, Bioadvantex, Bionomics, Collaborative Medicinal Development, Janssen and Janssen, Lundbeck Merck, Pfizer and Servier – all unrelated to this work. MM has received grant/research support from the NHMRC, Deakin University School of Medicine, Deakin Biostatistics Unit, Institute for Mental and Physical Health and Clinical Translation, Stroke Foundation and Medibank Health Research Fund. FJ has received: competitive Grant/Research support from the Brain and Behaviour Research Institute, the National Health and Medical Research Council (NHMRC), Australian Rotary Health, the Geelong Medical Research Foundation, the Ian Potter Foundation, The University of Melbourne; industry support for research from Meat and Livestock Australia, Woolworths Limited, the A2 Milk Company, Be Fit Food; philanthropic support from the Fernwood Foundation, Wilson Foundation, the JTM Foundation, the Serp Hills Foundation, the Roberts Family Foundation, the Waterloo Foundation and travel support and speakers honoraria from Sanofi-Synthelabo, Janssen Cilag, Servier, Pfizer, Network Nutrition, Angelini Farmaceutica, Eli Lilly and Metagenics. FNJ has written two books for commercial publication. She is on the Scientific Advisory Board of the Dauten Family Centre for Bipolar Treatment Innovation and Zoe Limited. She is currently supported by an NHMRC Investigator Grant L1 (#1194982). No other authors report competing interests.
PubMed

What Lands in Your Inbox Each Week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free