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Probiotic Lactobacillus rhamnosus GG Prevents Liver Fibrosis Through Inhibiting Hepatic Bile Acid Synthesis and Enhancing Bile Acid Excretion in Mice
Probiotic Lactobacillus rhamnosus GG may prevent liver scarring by reducing bile acid production and increasing bile acid removal in mice
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Abstract
Lactobacillus rhamnosus GG (LGG) treatment significantly reduces hepatic bile acids and liver injury in bile duct ligation mice.
- LGG treatment attenuates liver inflammation, injury, and fibrosis in bile duct ligation mice.
- Hepatic levels of taurine-β-muricholic acid were significantly higher in untreated bile duct ligation mice compared to those treated with LGG.
- Chenodeoxycholic acid levels were decreased in untreated bile duct ligation mice but normalized with LGG treatment.
- LGG treatment increased the expression of fibroblast growth factor 15, which is associated with reduced bile acid synthesis.
- Alterations in gut microbiota due to LGG treatment are linked to increased bile acid deconjugation and enhanced bile acid excretion.
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Key numbers
significantly reduced
Decrease in liver fibrosis markers
Compared to BDL mice without LGG treatment.
significantly reduced
Reduction in hepatic CYP7A1 expression
Observed in BDL-operated mice treated with LGG.
significantly increased
Increase in FGF15 levels
In BDL mice following LGG treatment.