Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: A randomized, double-blind, placebo-controlled trial

May 23, 2016Diabetes & metabolism

Probiotics and their effects on blood sugar and fat levels in gestational diabetes

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Probiotic supplementation for 6 weeks in patients with gestational diabetes resulted in a 9.2 mg/dL decrease in fasting plasma glucose compared to a placebo.

Probiotic supplementation led to a significant reduction in serum insulin levels by -0.8 μIU/mL versus an increase of +4.5 μIU/mL in the placebo group.
The insulin resistance assessment showed a decrease of -0.4 in the probiotic group compared to an increase of +1.1 in the placebo group.
A positive change in β-cell function was observed, with an increase of +1.1 in the probiotic group relative to an increase of +18.0 in the placebo group.
The quantitative insulin sensitivity check index increased by +0.007 in the probiotic group, contrasting with a decrease of -0.01 in the placebo group.
Significant reductions in serum triglycerides and VLDL cholesterol concentrations were noted in the probiotic group compared to the placebo.

AI simplified

BACKGROUND: To our knowledge, data on the effects of probiotic supplementation on glycaemic control and lipid concentrations in patients with gestational diabetes mellitus (GDM) are scarce.

AIM: The aim of the present study was to determine the effects of probiotic supplementation on glycaemic control and lipid profiles in GDM patients.

METHODS: Sixty pregnant women with GDM, primigravida and aged 18-40years, were divided into two groups to receive either probiotic capsules (n=30) or a matching placebo (n=30) in this randomized double-blind, placebo-controlled trial. The patients in the probiotic group took a daily capsule that contained three viable freeze-dried strains: Lactobacillus acidophilus (2×10(9)CFU/g), L. casei (2×10(9)CFU/g) and Bifidobacterium bifidum (2×10(9)CFU/g) for 6weeks. The placebo group took capsules filled with cellulose for the same time period. Fasting blood samples were taken at the beginning and end of the study to quantify the relevant markers.

RESULTS: After 6weeks of intervention, probiotic supplementation vs a placebo resulted in significant decreases in fasting plasma glucose (-9.2±9.2mg/dL vs +1.1±12.2mg/dL, P<0.001), serum insulin levels (-0.8±3.1μIU/mL vs +4.5±10.6μIU/mL, P=0.01), homoeostasis model assessment (HOMA) for insulin resistance (-0.4±0.9 vs +1.1±2.5, P=0.003) and HOMA for β-cell function (+1.1±9.8 vs +18.0±42.5, P=0.03), and a significant increase in the quantitative insulin sensitivity check index (+0.007±0.01 vs -0.01±0.02, P=0.007). In addition, significant decreases in serum triglycerides (-1.6±59.4mg/dL vs +27.1±37.9mg/dL, P=0.03) and VLDL cholesterol concentrations (-0.3±11.9mg/dL vs +5.4±7.6mg/dL, P=0.03) were seen following supplementation with the probiotics compared with the placebo. However, no significant changes in other lipid profiles were seen with the intervention.

CONCLUSION: Overall, the results of our study have demonstrated that taking probiotic supplements for 6weeks in patients with GDM had beneficial effects on glycaemic control, triglycerides and VLDL cholesterol concentrations, although there was no effect on other lipid profiles.

Full Text

Full text is available at the source.

View full text (XML) ↗View full text ↗

Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: A randomized, double-blind, placebo-controlled trial

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief