The combined effects of probiotics and restricted calorie diet on the anthropometric indices, eating behavior, and hormone levels of obese women with food addiction: a randomized clinical trial

Oct 15, 2020Nutritional neuroscience

How probiotics and calorie restriction together may affect body measurements, eating habits, and hormone levels in obese women with food addiction

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Abstract

Probiotic administration significantly reduced weight, body mass index, and waist circumference in obese women with food addiction.

Weight, body mass index, waist circumference, waist to hip ratio, body fat percentage, and trunk fat percentage were all significantly lower in the probiotic group compared to the placebo group.
Eating behavior improved significantly in the probiotic group compared to the placebo group.
Serum oxytocin levels increased, while neuropeptide Y levels decreased significantly in the probiotic group.
Leptin levels significantly decreased from baseline in the probiotic group, but there was no greater reduction compared to the placebo group.

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BACKGROUND AND AIM: Food addiction (FA) is an important contributor to obesity. Alterations in gut microbiota (GM) diversity and composition have also been proposed to play a pivotal role in obesity pathogenesis. This trial aimed to assess the effects of probiotic supplementation on the anthropometric indices, eating behavior, and hormone levels of obese women with FA.

METHODS: This randomized, double-blind, placebo-controlled clinical trial was conducted among obese women with FA. Participants (= 62) received a restricted calorie diet (RCD) plus either probiotic, or placebo for 12 weeks. Anthropometric measurements, biochemical markers, eating behavior and appetite were assessed during the study period. n

RESULTS: Probiotics administration significantly reduced weight, body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR), body fat percentage (BFP), and trunk fat percentage (TFP) compared to the placebo group (< 0.001). Also, a significant improvement was observed in eating behavior in the probiotic group compared to the placebo group (< 0.001).Serum levels of oxytocin increased and NPY decreased significantly in the probiotic group compared to the placebo group (= 0.02, = 0.002, respectively). Moreover, leptin level significantly decreased in the probiotic group compared to the baseline values (< 0.001), while probiotics did not cause a greater significant reduction in leptin level, compared to the placebo group. p p p p p

CONCLUSION: Multi-probiotic supplementation may have beneficial effects on anthropometric indices, eating behavior, and some appetite-regulating hormones in obese women with FA.Iranian Registry of Clinical Trials identifier: IRCT20131228015968N5. Trial registration:

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The combined effects of probiotics and restricted calorie diet on the anthropometric indices, eating behavior, and hormone levels of obese women with food addiction: a randomized clinical trial

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