Effect of time restricted feeding on anthropometric measures, eating behavior, stress, serum levels of BDNF and LBP in overweight/obese women with food addiction: a randomized clinical trial

Jul 12, 2023Nutritional neuroscience

Time-Restricted Eating and Its Impact on Body Measurements, Eating Habits, Stress, and Blood Levels of Brain and Inflammation Markers in Overweight Women with Food Addiction

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Abstract

Significant reductions in weight, body mass index (BMI), waist circumference, and body fat mass were observed in the time-restricted feeding (TRF) group compared to the control group at week 8.

The TRF group experienced greater reductions in weight, BMI, waist circumference, and body fat mass with p-values of 0.018, 0.015, 0.03, and 0.036, respectively.
Cognitive restriction scores were significantly higher in the TRF group compared to the control group (p = 0.002).
Both groups showed a significant reduction in food addiction criteria scores (p < 0.001).
Serum levels of brain-derived neurotrophic factor (BDNF) significantly increased in the TRF group (p < 0.001).
A positive correlation was found between BDNF levels and cognitive restriction scores (r = 0.468, p < 0.001), while no significant correlation with food addiction was observed (β = 0.588, p = 0.618).
Lipopolysaccharide binding protein decreased in both groups, but the decrease was significantly greater in the TRF group (p < 0.001).

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BACKGROUND & AIM: Food addiction (FA) as a specific food-related behavior may play an essential role in the pathogenesis of obesity. Brain-derived neurotrophic factor (BDNF) and gut microbiota (GM) alterations probably through fasting are closely related to brain function, affecting eating behaviors and body weight management. This study aimed to evaluate the effect of time-restricted feeding (TRF) on serum BDNF levels and eating behaviors in overweight and obese women with FA.

METHODS AND DESIGN: This clinical trial was performed with a 2-month follow-up on 56 obese and overweight women with FA. Participants were randomly divided into two groups receiving a low-calorie diet (n = 27) and a group receiving a low-calorie diet with TRF (n = 29). Anthropometric measurements, biochemical markers, eating behavior, and stress were assessed during the study period.

RESULTS: The reductions in weight, body mass index (BMI), waist circumference, and body fat mass were significantly higher in the TRF group compared to the control group at week 8 ( = 0.018, = 0.015. = 0.03, and = 0.036, respectively). The cognitive restriction score was higher in the TRF as compared with the control group ( = 0.002). The food addiction criteria score was significantly reduced in both groups ( < 0.001). Serum levels of BDNF were significantly increased in the TRF group ( < 0.001). In addition, BDNF levels had a positive and significant correlation with the cognitive restriction score (r = 0.468 and < 0.001), While the correlation with FA was not significant (β = 0.588 and = 0.618). Lipopolysaccharide binding protein decreased significantly in both groups, but this decrease was significantly higher in the TRF group than in the control group ( < 0.001). P P P P P P P P P P

CONCLUSION: The results of this study showed that a low-calorie diet with TRF is more effective in weight management than a low-calorie diet alone, probably through further modulating the GM and improving BDNF levels. More effective weight loss in the TRF is probably related to better management of eating behavior than FA.

TRIAL REGISTRATION: Iranian Registry of Clinical Trials identifier: IRCT20131228015968N7.

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Effect of time restricted feeding on anthropometric measures, eating behavior, stress, serum levels of BDNF and LBP in overweight/obese women with food addiction: a randomized clinical trial

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