Cancer cell

Progenitor-like exhausted SPRY1+ CD8+ T cells may increase response to PD-1 blocking treatment before surgery in esophageal cancer

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

A subset of exhausted CD8T cells expressing SPRY1 is associated with complete response to neoadjuvant immune checkpoint blockade in esophageal squamous cell carcinoma.

  • Single-cell RNA sequencing reveals a specific group of CD8T cells, termed CD8Tex-SPRY1, that shows characteristics of a progenitor exhausted T cell phenotype.
  • The presence of CD8Tex-SPRY1 cells correlates with improved response and survival rates in patients receiving immune checkpoint blockade.
  • CD8Tex-SPRY1 cells are validated as predictors of treatment efficacy in both immune checkpoint blockade and non-immune checkpoint blockade cohorts.
  • Expression of SPRY1 in CD8T cells reinforces the progenitor exhausted T cell phenotype and may enhance the effectiveness of immune checkpoint blockade.
  • CD8Tex-SPRY1 cells also influence macrophage behavior and B cell function, contributing to stronger antitumor immune responses.

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Funding

Competing interests

Declaration of interests B.K. serves as the speaker and advisory board for AstraZeneca, Merck, Medtronic. F.D. received research support to the institution from Amgen, Astrazeneca, BMS, Exelixis, Genentech, Ipsen, Signatera, Taiho; has received consulting fees from Astrazeneca, Eisai, Exelixis, Genentech, Foundation Medicine, Ipsen and served on the speakers bureau for Amgen, Deciphera, Eisai, Exelixis, Ipsen, Servier, Signatera, Sirtex. F.D.’s spouse is employed by Roche Diagnostics U.S.
PubMed

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