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Progenitor-like exhausted SPRY1+CD8+ T cells potentiate responsiveness to neoadjuvant PD-1 blockade in esophageal squamous cell carcinoma
Progenitor-like exhausted SPRY1+ CD8+ T cells may increase response to PD-1 blocking treatment before surgery in esophageal cancer
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Abstract
A subset of exhausted CD8T cells expressing SPRY1 is associated with complete response to neoadjuvant immune checkpoint blockade in esophageal squamous cell carcinoma.
- Single-cell RNA sequencing reveals a specific group of CD8T cells, termed CD8Tex-SPRY1, that shows characteristics of a progenitor exhausted T cell phenotype.
- The presence of CD8Tex-SPRY1 cells correlates with improved response and survival rates in patients receiving immune checkpoint blockade.
- CD8Tex-SPRY1 cells are validated as predictors of treatment efficacy in both immune checkpoint blockade and non-immune checkpoint blockade cohorts.
- Expression of SPRY1 in CD8T cells reinforces the progenitor exhausted T cell phenotype and may enhance the effectiveness of immune checkpoint blockade.
- CD8Tex-SPRY1 cells also influence macrophage behavior and B cell function, contributing to stronger antitumor immune responses.
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