CRISPR-Cas12a2 kills cells by recognizing specific RNA

CRISPR-Cas12a can eliminate yeast and human cells with single-nucleotide resolution specificity.

• The technology utilizes RNA-triggered DNA shredding to target specific cells.
• It demonstrates the ability to eliminate cells expressing identified transcripts.
• Off-target activity remains non-detectable, suggesting high precision.
• This approach may enable programmable cell removal in various applications.

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