Protein coingestion stimulates muscle protein synthesis during resistance-type exercise

Protein coingestion with carbohydrates during resistance exercise increased protein synthesis rates by 33 +/- 3%.

• Protein coingestion lowered whole body protein breakdown rates by 8.4 +/- 3.6% compared to carbohydrate ingestion alone.
• Protein oxidation rates increased by 77 +/- 17% with protein coingestion.
• Whole body net protein balance was negative with carbohydrates only but positive with protein coingestion (-4.4 +/- 0.3 vs. 16.3 +/- 0.4 micromol phenylalanine x kg(-1) x h(-1)).
• Mixed muscle protein fractional synthesis rates were 49 +/- 22% higher after protein coingestion compared to carbohydrate alone (0.088 +/- 0.012 vs. 0.060 +/- 0.004%/h).
• These findings suggest that protein coingestion may stimulate protein synthesis during exercise even when already fed.

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