A comprehensive map showing how protein interaction sites depend on each other across all proteins

A base-editing screen mapped hundreds of short linear protein motifs that human cells need for normal proliferation.

Proteome-wide cell-screening resource study tested 80,473 mutations across 7,293 SLiM-containing regions in HAP1 cells, with reproducibility checked in RPE1 cells.

Essentiality was measured mainly as proliferation in cultured cell lines, so functions outside those cells and growth conditions remain unresolved.