Using Protein Studies to Understand the Body's Internal Clock

Circadian gene expression studies have shown that many protein-encoding genes exhibit circadian expression in a tissue-specific manner.

• The circadian clock helps organisms adjust physiology and behavior based on the time of day.
• Regulation of gene expression at both the transcriptional and post-transcriptional levels is coordinated by the circadian clock.
• Rhythmic protein oscillation is influenced by gene transcription, as well as post-transcriptional and post-translational regulations.
• New advances in mass spectrometry are providing insights into the circadian dynamics of proteins.
• Understanding the circadian clock's role in gene regulation levels is an emerging challenge in this research area.

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