Pharmacological Interventions to Circadian Clocks and Their Molecular Bases

Small-molecule modulators of clock proteins may adjust circadian functions and offer therapeutic avenues for related diseases.

• The circadian clock regulates daily physiological rhythms through controlled expression and modification of clock proteins.
• Disruptions to the circadian clock can lead to physiological dysfunction and various diseases.
• Small molecules targeting clock proteins can potentially modify clock functions.
• X-ray crystal structures of protein-compound complexes aid in understanding the regulation of clock proteins.
• The review discusses the potential therapeutic effects of these compounds in disease contexts.

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