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Abstract
Cells rely on regulated proteostasis mechanisms to maintain proteome integrity within distinct subcellular compartments.
- Proteostasis involves protein synthesis, folding, trafficking, and degradation.
- Disruption of proteostasis can lead to the accumulation of damaged proteins.
- Accumulated damage may progressively compromise organelle function.
- Organelle dysfunction is associated with aging and age-related disorders, including neurodegeneration and cancer.
- Insights into proteostasis could inform therapeutic strategies for promoting healthy aging.
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