Psilocybin Therapy for Existential Distress in Brain Cancer: A Case Report

A patient with end-of-life distress from stage 4 astrocytoma reported a positive response to psilocybin-assisted therapy without adverse events.

• Psilocybin-assisted therapy has shown potential in alleviating existential distress in patients with serious illness.
• Patients with brain cancer, like the one discussed, are often excluded from studies on psilocybin-assisted therapy.
• Standard treatments for existential distress may be ineffective, leading some patients to consider medical assistance in dying.
• The case underscores the need for broader access to psilocybin-assisted therapy for patients facing unresolved existential distress.

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