Psilocybin-assisted therapy for depression: A systematic review and meta-analysis

Oct 16, 2023Psychiatry research

Psilocybin-assisted therapy for depression: A summary and combined analysis of studies

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Abstract

A large effect size of -0.78 was found in depression severity favoring psilocybin treatment.

Thirteen studies with a total of 686 participants were included in the review.
The meta-analysis comprised nine studies with 596 participants.
Psilocybin therapy is associated with significant reductions in depressive symptoms.
Risk ratios for response and remission were large and significant in favor of psilocybin.
Open-label trials indicated robust decreases in depressive symptoms after psilocybin administration.
Further studies are needed to evaluate safety and efficacy as well as to optimize treatment protocols.

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The aim of this review was to determine the effect of psilocybin on depressive symptoms in patients diagnosed with life-threatening illnesses or major depressive disorder. Systematic searches were conducted to search for randomized clinical trials and open-label trials that evaluated depression symptoms after psilocybin therapy. Data was pooled using a random-effects model. The primary outcome was the standardized mean difference (SMD) in depression severity, determined by calculating the change in depression ratings from baseline to the primary endpoint in the psilocybin arm versus the control arm. The literature search yielded 1734 studies, and 13 studies (n = 686) were included in either qualitative and/or quantitative analyses. The meta-analysis included 9 studies (pooled n = 596) and yielded a large effect size in favour of psilocybin (SMD = -0.78; p<0.001). Risk ratios for response and remission were large and significant in favour of psilocybin. A review of open-label trials showed robust decreases in depressive symptoms following psilocybin administration. These findings provide preliminary evidence for antidepressant efficacy with psilocybin-assisted psychotherapy, however, further studies are needed to evaluate safety and efficacy and to optimize treatment protocols.

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Psilocybin-assisted therapy for depression: A systematic review and meta-analysis

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