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Abstract
Approximately 40 million individuals worldwide are affected by bipolar disorder, with depression being the most prominent phase.
- Bipolar depression is associated with significant functional impairment and increased suicide risk.
- Current treatments often lack rapid effectiveness, indicating a need for new therapeutic approaches.
- Psilocybin is being investigated for its potential rapid antidepressant effects in combination with psychotherapy.
- Early studies in bipolar II disorder (n = 19) have shown encouraging results, but evidence remains limited.
- Safety concerns include affective switching and possible interactions with existing bipolar medications.
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