Full text is available at the source.
Psilocybin Decreases Preference for Large Rewards Accompanied by Increased Activity of Parvalbumin Neurons With Perineuronal Nets in the Medial Prefrontal Cortex
Psilocybin reduces preference for big rewards while increasing activity of specific inhibitory neurons in the brain's decision-making area
AI simplified
Abstract
A single dose of psilocybin decreased large reward choices in rats 48 hours after administration.
- Psilocybin acutely increased head-twitch responses in male Long Evans rats.
- Forty-eight hours post-injection, psilocybin reduced the number of choices for large rewards.
- Latency to choose large rewards also increased after psilocybin treatment.
- These changes in reward choice were not influenced by the delay in reward availability.
- Psilocybin increased the density of neurons marked by perineuronal nets, parvalbumin, and c-Fos in the dorsomedial prefrontal cortex.
- The findings indicate a potential mechanism where psilocybin may reduce motivation for immediate rewards through increased activity of specific interneurons.
AI simplified