Different psilocybin compounds affect fentanyl reward behavior in male and female mice

Fentanyl is the leading cause of fatal overdoses worldwide.

• Repeated use of fentanyl may lead to substance use disorder (SUD).
• In SUD, environments associated with drug use can trigger cravings and reward-seeking behavior even when the drug is absent.
• Psychedelic compounds may potentially weaken the associations between drug contexts and drug-related rewards.
• This weakening could reduce the reward-driven behavior linked to fentanyl.

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