Changes in brain activity and connections caused by psilocybin in healthy people linked to their experiences and possible therapy uses

Psilocybin significantly decreased EEG power in slow frequency bands and increased it in fast frequency bands compared to placebo.

• Psilocybin administration resulted in decreased power in theta and alpha frequency bands.
• There was an increase in power in beta, gamma1, and gamma2 frequency bands following psilocybin administration.
• Connectivity within the default-mode network and localized parietal network increased under psilocybin.
• Subjective experiences correlated positively with EEG power and connectivity changes during psilocybin use.
• Baseline EEG features may predict individual subjective experiences during psilocybin therapy.

Simplified