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Psilocybin-induced alterations in EEG power, connectivity and network dynamics in healthy subjects: Correlations with subjective experience and implications for therapeutic applications
Changes in brain activity and connections caused by psilocybin in healthy people linked to their experiences and possible therapy uses
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Abstract
Psilocybin significantly decreased EEG power in slow frequency bands and increased it in fast frequency bands compared to placebo.
- Psilocybin administration resulted in decreased power in theta and alpha frequency bands.
- There was an increase in power in beta, gamma1, and gamma2 frequency bands following psilocybin administration.
- Connectivity within the default-mode network and localized parietal network increased under psilocybin.
- Subjective experiences correlated positively with EEG power and connectivity changes during psilocybin use.
- Baseline EEG features may predict individual subjective experiences during psilocybin therapy.
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