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Abstract
Psilocybin may have therapeutic effects for depression by enhancing neuronal plasticity.
- Psilocybin could act on multiple serotonin receptor subtypes rather than just serotonin 2A (5-HT) receptors.
- It may also interact with nonserotonergic targets like TrkB.
- Understanding the molecular interactions of psilocin can help clarify how psilocybin works.
- These findings could inform the creation of safer and more effective neuroplastogens in the future.
- The review highlights the importance of receptor selectivity and biased agonism in psilocybin's effects.
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