Psilocybin as a serotonin-based treatment for epilepsy: potential benefits and challenges

Strong agreement (88.9%) was found in assessing the risk of bias across studies on psilocybin and seizures.

• Psilocybin may have antiseizure effects through activation of specific serotonin receptors.
• Preclinical evidence suggests that serotonergic modulation could be a promising strategy for managing seizures.
• Clinical data indicate that psilocybin does not increase seizure risk in neuropsychiatric patients under medical supervision.
• Conflicting evidence and concerns about high doses of psilocybin highlight the need for caution.
• Future animal studies and clinical trials are necessary to confirm psilocybin's safety and efficacy for epilepsy treatment.

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