Psilocybin’s traditional uses and possible medical benefits: a detailed review of how it works and current views

Psilocybin's pharmacokinetics and pharmacodynamics involve serotonergic, neuroplastic, and anti-inflammatory mechanisms.

• Psilocybin may influence serotonin receptors, which are linked to mood and perception.
• The compound is associated with neuroplasticity, potentially supporting brain adaptability and healing.
• Anti-inflammatory properties of psilocybin could contribute to its therapeutic effects.
• The review evaluates both preclinical and clinical evidence surrounding psilocybin's safety.
• Emerging practices like microdosing are discussed regarding their potential benefits and risks.

Simplified