The Lancet regional health. Europe

Psilocybin Therapy for Hard-to-Treat Depression in Real-Life Settings: A Look Back Study

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Abstract

Psilocybin therapy for treatment-resistant depression (TRD) is being examined for its antidepressant outcomes and safety in real-world settings.

  • Preliminary findings suggest psilocybin may have antidepressant effects in individuals with TRD.
  • The study investigates the safety of psilocybin therapy, which remains largely unknown in therapeutic contexts.
  • Feasibility of conducting psilocybin therapy with repeated dosing sessions is being assessed.
  • Psilocybin is currently not approved as an antidepressant but is permitted for limited medical use in Switzerland.

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