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Abstract
A total of 115 patients with treatment-resistant depressive and/or anxiety disorders showed significant improvements in symptoms after a first session of psychedelic-assisted psychotherapy.
- Depressive symptoms decreased significantly, with a strong statistical effect (BDI: F(2178) = 63.50, p < 0.001).
- Anxiety symptoms also showed significant reduction (STAI-T: F(1.74,145.9) = 16.97, p < 0.001).
- Cognitive emotion regulation analysis indicated reduced self-blame, rumination, and catastrophizing, alongside increased positive emotional strategies.
- Participants experienced distinct temporal profiles for the perceived intensity of LSD and psilocybin, but overall subjective effects were comparable.
- Adverse events reported were mostly mild and transient, with no serious complications or treatment discontinuations noted.
Simplified
Psychedelic Science